How does Trimix Gel Differ From Impotence Injections?

We have had many inquiries about Trimix gel, and how it differs from the injectable version of the medication.  The fact is it's the  the same exact combination of drugs, just a different method of delivery.

Let's take a closer look...

Trimix is a viable option for erectile dysfunction when other methods, including oral impotence drugs like Viagra and Cialis, as well as lifestyle changes, supplements, etc. don't work for one reason or another.

Originally the combination, which includes three different drugs (hence the name) was only available in injectable form, which had to be refrigerated and then self-injected.

The company then came out with Trimix gel which is a topical application, so it does not have to be injected.  It can also be stored at room temperature making it much more convenient to use.

The three drugs in Trimix injectable are alprostadil, papaverine and phentolamine.  All three can be administered as single ED injections as well.  The gel substitutes prostaglandin for alprostadil, but it is essentially the same compound.

How do you get Trimix gel?

Trimix gel and injections are not readily available commercially, so they need to be prepared by specialty pharmacies.  The three individual drugs are easier to come by, but for the two or three drug combos (Bimix and Trimix) only certain pharmacies offer them.

The gel is probably easier to come by as they now have an online patient prescription form that you can show to your doctor and have them fax it over to the company for you.

Either way, you need to discuss it with your doctor to see if the injectable or the gel are the right option for you?

What about side effects of Trimix?

Since both the injections and gels contain the same ingredients, they also share the same potential side effects and adverse reactions.

Interestingly, this information is not readily available so we had to do a little digging to find out.

The Trimix injections could cause a condition called Peyronie's Disease, which is a painful curvature of the penis caused by plaque or scar tissue buildup.  However this is quite rare and if you inject properly this will likely not be an issue.

The three medicines all have their own potential complications:  

Alprostadil can cause hives, priapism (erection lasting over 3 hours), dizziness and pain.  

Papaverine could cause all of these as well as liver damage, diarrhea, nausea and sweating.

Phentolamine can cause hives, priapism, low blood pressure, nausea and an increased or decreased heart beat.

Trimix gel is likely a bit safer as it doesn't involve repeated injections.  Yet it still contains the same medications and therefore can still cause the same side effects.  Injections are also likely more effective as it is often difficult for the drugs to penetrate the skin.

What's the bottom line?

If other medications and treatments are simply not working for you, injections or gels can be a viable option.

If the thought of injecting yourself doesn't bother you, then you are probably better off doing that than trying the gel.  However, if the thought of an injection makes you cringe, the gel is likely your best bet.

Either way, talk to your doctor about Trimix gel or injection and see if he/she recommends it for you.  It's a powerful combination, but one that is successful in 90% of men.  So it does work.  Just be aware of potential side effects and complications.